Evaluation of Thyroid Function Test in Sudanese Patients with Type 2 Diabetes Mellitus
Walla Mustafa Saeed, Shereen Faisal Abd ElRahman and
AbdElkarim A. Abdrabo
Full Length Research Paper I Published August, 2016
Journal of Medical and Biological Science Research Vol.
2 (8), pp. 131-135
ABSTRACT
Diabetes mellitus (DM) is a very common endocrinal disorder
with inappropriate hyperglycemia due to either an absolute
deficiency of insulin secretion or a reduction in the
biological effectiveness of insulin or both. The present
study was carried out aiming to evaluate thyroid function in
patients with type 2 DM. In this case-control study, a total
of 90 subjects were recruited to participate, where 45
subjects were diagnosed as type 2 DM as the study group and
other 45 subjects were apparently healthy as control group
to evaluate the effect of DM on thyroid function. Thyroid
dysfunction was evaluated by investigating the subjects for
Total tri-iodo–thyronine (T3), Total thyroxine (T4) and
thyroid stimulating hormone (TSH). All these parameters were
measured by using ELISA technique, fasting plasma glucose (FPG),
and glycated hemoglobin (HbA1C) were measured
spectrophotometrically. Statistical analysis was performed
using software statistical package for social sciences (SPSS)
version 21 using independent samples test, Pearson`s
correlation. Independent samples test analyses showed a
significant decrease in mean level of T3, T4 (p<0.05) for
both, while significant increase was observed in TSH level
(p<0.05) when compared with the control group. Person's
correlation reveals that there were insignificant positive
correlation between FPG, HbA1c and duration of DM with the
study parameters (T3 and T4) with p> 0.05 and insignificant
negative correlation between FPG, HbA1c and duration of DM
with the study parameter (TSH) with p> 0.05. Abnormal
thyroid function was found to be higher in type 2 diabetes
mellitus subjects when compared to non-diabetic subjects.
Key words: Diabetes mellitus, Hypothyroidism, T3, T4,
TSH.
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