Evaluation of Thyroid Function Test in Sudanese Patients with Type 2 Diabetes Mellitus


Walla Mustafa Saeed, Shereen Faisal Abd ElRahman and AbdElkarim A. Abdrabo


Full Length Research Paper I Published August, 2016


Journal of Medical and Biological Science Research Vol. 2 (8), pp. 131-135



Diabetes mellitus (DM) is a very common endocrinal disorder with inappropriate hyperglycemia due to either an absolute deficiency of insulin secretion or a reduction in the biological effectiveness of insulin or both. The present study was carried out aiming to evaluate thyroid function in patients with type 2 DM. In this case-control study, a total of 90 subjects were recruited to participate, where 45 subjects were diagnosed as type 2 DM as the study group and other 45 subjects were apparently healthy as control group to evaluate the effect of DM on thyroid function. Thyroid dysfunction was evaluated by investigating the subjects for Total tri-iodo–thyronine (T3), Total thyroxine (T4) and thyroid stimulating hormone (TSH). All these parameters were measured by using ELISA technique, fasting plasma glucose (FPG), and glycated hemoglobin (HbA1C) were measured spectrophotometrically. Statistical analysis was performed using software statistical package for social sciences (SPSS) version 21 using independent samples test, Pearson`s correlation. Independent samples test analyses showed a significant decrease in mean level of T3, T4 (p<0.05) for both, while significant increase was observed in TSH level (p<0.05) when compared with the control group. Person's correlation reveals that there were insignificant positive correlation between FPG, HbA1c and duration of DM with the study parameters (T3 and T4) with p> 0.05 and insignificant negative correlation between FPG, HbA1c and duration of DM with the study parameter (TSH) with p> 0.05. Abnormal thyroid function was found to be higher in type 2 diabetes mellitus subjects when compared to non-diabetic subjects.

Key words: Diabetes mellitus, Hypothyroidism, T3, T4, TSH.

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