Anti-prostate cancer, and chemiluminescence activities of some selected Sudanese Medicinal plants

 

Montasir Ahmed Elnour, Mohamed Ahmed Mesaik and Asaad Khalid
 

Full Length Research Paper I Published April, 2018

 

Journal of Medical and Biological Science Research Vol. 4 (1), pp. 11-16

 

ABSTRACT

Plants have been used in treating human diseases for thousands of years; Sudanese medicinal plants used locally in traditional medicine to treat wide range of diseases were investigated for their anticancer, antioxidant activities and Cytotoxicity. This work was carried out to investigate the anticancer, antioxidant and cytotoxicity activities of four Sudanese medicinal plants commonly used as anti-inflammatory and anti-tumor. Hibiscus sabdariffa L fruits, Sonchus oleraceus L.leaves, Halexylon salicornietum (MAB) whole plant, Prosopis juliflora (SW.) DC leaves. All the plant parts were extracted using 80% methanol, the anticancer activity was examined by using MTT assay against PC3 (prostate cancer) cell lines. and determine their antioxidant activities by testing Chemiluminescence activity, screened for their cytotoxicity using - (4, 5-Dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium  bromide (MTT), filter and kept in dark, prepared freshly. The extract Prosopis juliflora (SW.) DC is showed very high against-PC3 and Hibiscus sabdariffa is showed high against-PC3 the extract of Halexylon salicornietum and Sonchus oleraceus L is showed none active anti- PC3 with IC₅₀ values 30.1 , 94.7, > 100, and > 100 μg/ml respectively. All the extracts revealed cytotoxicity activity against Vero cell line except last concentration in extract of Sonchus oleraceus L, and the inhibition percentage with (90.56,87.12,86.24) (82.78,82.31,77.38) (75.21,59.49,41.24) (74.93,73.78,71.13) respectively. The extracs of Hibiscus sabdariffa, Halexylon salicornietum and Sonchus oleraceus L. are revealed low active against Chemiluminescence  assay, Prosopis juliflora (SW.) DC is revealed high active against Chemiluminescence  assay.with IC₅₀ values  166.6, 189.5, > 176.2 and 75.4 μg/ml respectively.

Key words: Anticancer, medicinal plants, cytotoxicity,  PC3, chemiluminescence.

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