Repository Effects of Methanolic Leaf Extract of Albizia Chevalieri on Plasmodium Berghei using Albino Wistar Rats

 

Hajara Sani Labaran, Samaila A. B., A. F Umar, Rabiu Sahal, Morumda Daji, A. kwaji, Paul Mela Leonard and Muktar Adamu Difa
 

 

Full Length Research Paper I Published September, 2017

 

Journal of Medical and Biological Science Research Vol. 3 (4), pp. 32-36

 

ABSTRACT

Malaria is a serious hazard to humanity and the major cause of mortality and morbidity in the malaria endemic countries, and the emergence of resistance to currently used antimalarial drugs makes it imperative to search for newer, more effective therapeutic agents of which Albizia species have been reported to have a potential antiplasmodial effect. The purpose of this investigation was to determine the repository effects of methanolic leaf extract of Albizia chevalieri on Plasmodium berghei using albino wistar rats. The crude methanol extract of A. chevalieri leaves was investigated for its antimalarial activity against P.berghei (NK65) during established infections. The level of parasitemia, mean survival time was used to determine the antimalarial activity of the extract. The Phytochemical screening of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The leaf extract demonstrated significant (P<0.01) dose dependent activity against the parasite and also had repository activity. Leaf extract also prolonged the survival time of the infected rats. It was also revealed that LD₅₀ of the plant extract is greater than or equals 3000 mg/kg. The results showed that the leaf extract of the plant has potential antiplasmodial activity, which can be exploited in malaria therapy. Accordingly with the essence of further studies, this plant could serve as a potential source of new and novel antimalarial drug for the control of malaria.

Key words: Albizia chevalieri, Parasitaemia, Plasmodium berghei, Repository and Suppression.

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